Stress related research papers - Cambridge Nutritional Sciences

Stress related research papers

  1. Role of cold and emotional stress in Raynaud's disease and scleroderma (Freedman and Ianni, 1983)                                                                                                In Raynaud's disease about one third of the vasospastic attacks were associated with tachycardia and increased stress ratings without declines in ambient temperature. This study highlights the importance of effectively managing emotional stress for individuals with Raynaud's disease.
  2. Lipid Replacement as an Adjunct to Therapy for Chronic Fatigue, Anti-Aging and Restoration of Mitochondrial Function (Nicolson, 2003)                                                           When individuals experience fatigue, their mitochondrial function is inevitably diminished, indicating that mitochondrial function seems to be directly linked to fatigue. On a biochemical level, as fatigue is interconnected to the metabolic energy available to tissues and cells, the integrity of cellular and intracellular membranes, especially in the mitochondria (where aerobic ATP is produced), is critical to cell function and energy metabolism. When the mitochondrial membranes are damaged by oxidation, they need to be repaired or replaced in order to sustain the production of cellular energy to alleviate fatigue. This study found that Lipid Replacement Therapy is a valuable tool in helping to maintain mitochondrial function, reducing fatigue by approximately 40%, from severe to moderate after eight weeks.  
  3. Acute eVects of walking in forest environments on cardiovascular and metabolic parameters (Li et al, 2012)                                                                                                                       Habitual walking in forest environments may lower blood pressure by reducing sympathetic nerve activity (reducing urinary noradrenaline levels) and  increasing parasympathetic nerve activity. 
  4. The Hypothalamic-Pituitary-Adrenal Axis, Obesity, and Chronic Stress Exposure: Sleep and the HPA Axis in Obesity (Lucassen and Cizza, 2012)                      Chronic stress associated hyperactivation of the HPA axis and subsequent hypercortisolism result in increased fat storage particularly in the visceral region, further contributing to the related metabolic adverse consequences. The present review underlines, how the HPA axis play an essential role in the developing obesity epidemic of Western society, where high levels of ambient stress and availability of high fat, sweet foods are abundantly present. 
  5. Meditation and Yoga can Modulate Brain Mechanisms that affect Behavior and Anxiety-A Modern Scientific Perspective (Krishnakumar et al, 2015)                                 Our brains do not contain fixed hardwiring; the neural pathways and circuits can in fact change with learning and with mental exercises, and meditation may be a harmless way to encourage the growth of new neurons (neurogenesis) along with the formation of new connections between existing neurons (synaptogenesis). By tying together the neurobiological effects of neurotransmitters, brain waves, mental exercise and the empirical evidence from the psychological experiments, it is evident that meditation is an effective treatment for anxiety, and it does not suffer from any side effects. It may also function as a preventive medicine; therefore, it is highly recommended to everyone and not limited to patients suffering from disease. 
  6. Inflammation: The Common Pathway of Stress-Related Diseases                                  (Liu et al., 2017)                                                                                                                                                         In this review article, we provide evidence that stress induces or worsens CVD, NAFLD, depression, neurodegenerative disease and cancer through peripheral inflammation as well as neuroinflammation.
  7. Chronic stress and intestinal barrier dysfunction: Glucocorticoid receptor and transcription repressor HES1 regulate tight junction protein Claudin-1 promoter (Zheng et al, 2017)                                                                                                                           Chronic stress and subsequently elevated levels of glucocorticoid hormones are associated with decreases in the intestinal epithelial tight junction proteins. This suggests that chronic stress impairs colon epithelium homeostasis and barrier function. Intestinal epithelial tight junction proteins contribute to intestinal barrier function via their role in regulating paracellular permeability. Impaired intestinal barrier function involving increased epithelial paracellular permeability has been reported in several gastrointestinal disorders including IBS.