Vitamin D Deficiency (Holick, 2007) Undiagnosed vitamin D deficiency is not uncommon and 25-hydroxyvitamin D is the barometer for vitamin D status. Serum 25-hydroxyvitamin D is not only a predictor of bone health, but is also an independent predictor of risk for cancer and other chronic diseases.
Vitamin D and Depression: Where is all the Sunshine? (Penckofer et al, 2010) If exercising outdoors in the sunshine, eating foods rich in vitamin D, and/or taking dietary supplements to improve vitamin D deficiency could improve one’s mental well being, it would be a simple and cost-effective solution for many who are at risk for depression and possibly other mental disorders.
Vitamin D and gastrointestinal diseases: inflammatory bowel disease and colorectal cancer (Raman et al, 2011) There is rapidly increasing epidemiological and strong experimental evidence, suggesting a role for vitamin D in IBD and CRC. Although data to date have been demonstrated in largely in vitro studies and murine models of IBD, it is clear that vitamin D potentially has potent immunomodulatory actions on the T-cellmediated processes implicated in the pathogenesis of IBD, both at DC and T-cell level. In light of this evidence, well-conducted clinical trials of vitamin D or its analogues in human IBD patients are strongly indicated to assess further the potential therapeutic immunomodulatory properties of this much underestimated nutrient.
Vitamin D analogs in the treatment of psoriasis (Trémezaygues and Reichrath, 2011) Numerous studies have identified an association between polymorphisms in the vitamin D receptor (VDR) and the predisposition to psoriasis. With vitamin D being involved in the maintenance of cutaneous barrier equilibrium, significant associations between low vitamin D status and psoriasis have systematically been observed. For several years it has been demonstrated that vitamin D compounds are effective and safe in the topical treatment of psoriasis. In future, creating vitamin D analogues that activate selective vitamin D signalling pathways, but exert only minor calcaemic activity, would introduce a new era in dermatological therapy in the form of topical and systemic treatments for a variety of inflammatory skin diseases.
Vitamin D Deficiency and Its Association with Thyroid Disease (Mackawy et al, 2013) Our results indicated that patients with hypothyroidism suffered from hypovitaminosis D with hypocalcaemia that is significantly associated with the degree and severity of the hypothyroidism. That encourages the advisability of vit D supplementation and recommends the screening for Vitamin D deficiency and serum calcium levels for all hypothyroid patients.
Systematic Review of the Relationship between Vitamin D and Parkinson’s Disease (Rimmelzwaan et al, 2016) This systematic review indicates that Parkinson's disease is associated with lower serum vitamin D levels. Secondly, higher vitamin D levels are associated with better balance, and vitamin D supplementation appears to have a positive effect on Parkinson's disease motor symptoms. Finally, results from rodent models suggest that vitamin D may also have a neuroprotective effect. Additional studies are needed to further explore and elucidate the symptomatic and potential neuroprotective effects of vitamin D in Parkinson’s disease.
Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity (Shaikh et al, 2016) Vitamin D deficiency is prevalent in asthmatic patients. Moreover higher asthma severity, poor asthma control, and frequent exacerbations in asthmatic patients are associated with lower levels of vitamin D and magnesium. Serum 25(OH)D and magnesium levels may serve as markers of asthma severity. So levels of these analytes should be monitored in asthmatic patients and should be corrected if found low.
The Relationship between Vitamin D and Glaucoma: A Kangbuk Samsung Health Study (Kim et al, 2016) Lower serum 25-hydroxyvitamin D3 concentration (an indicator of vitamin D levels) was significantly associated with an increased risk of glaucoma in women compared to those with higher 25-hydroxyvitamin D3. The results of this study indicated that vitamin D status independently affects glaucoma pathophysiology in women, although the study authors were unable to explain the exact mechanism responsible. They did conclude however, that with the presence of a primary factor, a low vitamin D level might leave the optic nerve more vulnerable to glaucoma.
Vitamin D and VDR in Gynecological Cancers—A Systematic Review (Deuster et al., 2017)A large number of studies have displayed the crucial role vitamin D and its receptor have in gynaecological cancers. Preclinical, as well as epidemiological evidence, supports vitamin D’s risk-reducing influence in gynaecologic carcinomas . It is a widely shared opinion that vitamin D supplementation decreases the risk of developing cancer.
The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention (Guo et al,2018) The role of Vitamin D in human cancers, including ovarian cancer, has been widely investigated, where it was proposed to play a protective and antitumorigenic role by regulating cellular proliferation and metabolism. In this review, we have shown that vitamin D status may be an independent predictor of prognosis in ovarian cancer patients.Vitamin D combination therapy improves antitumor effects allowing for potential clinical application. Supplement of vitamin D and calcium combination may be an efficient method for cancer prevention.
Vitamin D Deficiency and Antenatal and Postpartum Depression: A Systematic Review (Aghajafari et al, 2018) Based on the systemic evaluation of the previous literature in the field, there may be an association between lower vitamin D status and increased risk of depressive symptoms during and after pregnancy. While the quality of the available evidence was not always optimal due to lower methodologic quality of the studies, this review provides an analysis of the methodological issue that future supplementation studies need to consider in their research design.
Vitamin D3 Versus Gliadin: A Battle to the Last Tight Junction (Scricciolo et al, 2018) The positive impact of vitamin D on tight junctions could be used in celiac disease therapy to prevent the passage of peptides into the lamina propria, that enhances the inflammatory process.The findings related to intestinal barrier damage and the benefit from vitamin D use, suggest its application to other gluten-related disorders (such as non-celiac gluten sensitivity), where the presence of altered intestinal permeability is proven.