Vitamin D related research papers - Cambridge Nutritional Sciences

Vitamin D related research papers

  1. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis (Holick, 2003)                                                                                   Infants and young children who are vitamin D deficient may be imprinted for the rest of their lives with increased risks of type 1 diabetes, multiple sclerosis, rheumatoid arthritis, and many common cancers. Adults are at increased risk of common cancers and cardiovascular disease.
  2. Vitamin D Deficiency (Holick, 2007)                                                                                                             Undiagnosed vitamin D deficiency is not uncommon and 25-hydroxyvitamin D is the barometer for vitamin D status. Serum 25-hydroxyvitamin D is not only a predictor of bone health, but is also an independent predictor of risk for cancer and other chronic diseases.
  3. Vitamin D and Depression: Where is all the Sunshine? (Penckofer et al, 2010)          If exercising outdoors in the sunshine, eating foods rich in vitamin D, and/or taking dietary supplements to improve vitamin D deficiency could improve one’s mental well being, it would be a simple and cost-effective solution for many who are at risk for depression and possibly other mental disorders.
  4. Vitamin D and gastrointestinal diseases: inflammatory bowel disease and colorectal cancer (Raman et al, 2011)                                                                                      There is rapidly increasing epidemiological and strong experimental evidence, suggesting a role for vitamin D in IBD and CRC. Although data to date have been demonstrated in largely in vitro studies and murine models of IBD, it is clear that vitamin D potentially has potent immunomodulatory actions on the T-cellmediated processes implicated in the pathogenesis of IBD, both at DC and T-cell level. In light of this evidence, well-conducted clinical trials of vitamin D or its analogues in human IBD patients are strongly indicated to assess further the potential therapeutic immunomodulatory properties of this much underestimated nutrient.
  5. Vitamin D analogs in the treatment of psoriasis                                                                                 (Trémezaygues and Reichrath, 2011)                                                                                                       Numerous studies have identified an association between polymorphisms in the vitamin D receptor (VDR) and the predisposition to psoriasis. With vitamin D being involved in the maintenance of cutaneous barrier equilibrium, significant associations between low vitamin D status and psoriasis have systematically been observed.  
    For several years it has been demonstrated that vitamin D compounds are effective and safe in the topical treatment of psoriasis. In future, creating vitamin D analogues that activate selective vitamin D signalling pathways, but exert only minor calcaemic activity, would introduce a new era in dermatological therapy in the form of topical and systemic treatments for a variety of inflammatory skin diseases.
  6. Current Methods for Routine Clinical Laboratory Testing of Vitamin D Levels (Arneson and Arneson, 2013)                                                                                                                    Redefining what is considered to be a sufficient plasma level of 25-hydroxy vitamin D would potentially reclassify more people as vitamin D insufficient and trigger the need for treatment and monitoring of vitamin D levels.
  7. Vitamin D Deficiency and Its Association with Thyroid Disease                                        (Mackawy et al, 2013)                                                                                                                                         Our results indicated that patients with hypothyroidism suffered from hypovitaminosis D with hypocalcaemia that is significantly associated with the degree and severity of the hypothyroidism. That encourages the advisability of vit D supplementation and recommends the screening for Vitamin D deficiency and serum calcium levels for all hypothyroid patients.
  8. Hospitalisation for children with rickets in England: a historical perspective (Goldacre et al., 2014)                                                                                                          Hospitalisation rates for rickets in England are the highest in five decades. 
  9. Plausible ergogenic effects of vitamin D on athletic performance and recovery (Dahlquist et al., 2015)                                                                                                                  Vitamin D levels above the normal reference range (up to 100 nmol/L) might increase skeletal muscle function, decrease recovery time from training, increase both force and power production, and increase testosterone production, each of which could potentiate athletic performance.
  10. Chronic Ethanol Exposure Effects on Vitamin D Levels Among Subjects with Alcohol Use Disorder (Ogunsakin et al., 2016)                                                                                   Overall, we have shown from our results that excessive consumption of alcohol can significantly lower the levels of inactive vitamin D (25(OH)D3), active vitamin D (1, 25(OH)2 D3), and antimicrobial peptide cathelicidin/LL-37 among subjects with AUD, especially in minority populations.
  11. Mean Platelet Volume, Vitamin D and C Reactive Protein Levels in Normal Weight Children with Primary Snoring and Obstructive Sleep Apnea Syndrome                   (Zicari et al, 2016)                                                                                                                                                         The present study provides evidence of higher Mean Platelet Volume and lower vitamin D levels in children with Primary Snoring as well as in children with Obstructive Sleep Apnea Syndrome, and supports the underlying inflammation, hence, highlighting the importance of an early diagnosis of this previously considered benign form of Sleep Disordered Breathing.
  12. Systematic Review of the Relationship between Vitamin D and Parkinson’s Disease (Rimmelzwaan et al, 2016)                                                                                                               This systematic review indicates that Parkinson's disease is associated with lower serum vitamin D levels. Secondly, higher vitamin D levels are associated with better balance, and vitamin D supplementation appears to have a positive effect on Parkinson's disease motor symptoms. Finally, results from rodent models suggest that vitamin D may also have a neuroprotective effect. Additional studies are needed to further explore and elucidate the symptomatic and potential neuroprotective effects of vitamin D in Parkinson’s disease. 
  13. Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity (Shaikh et al, 2016)                                                                                                                                             Vitamin D deficiency is prevalent in asthmatic patients. Moreover higher asthma severity, poor asthma control, and frequent exacerbations in asthmatic patients are associated with lower levels of vitamin D and magnesium. Serum 25(OH)D and magnesium levels may serve as markers of asthma severity. So levels of these analytes should be monitored in asthmatic patients and should be corrected if found low.
  14. The Relationship between Vitamin D and Glaucoma: A Kangbuk Samsung Health Study (Kim et al, 2016)                                                                                                                                             Lower serum 25-hydroxyvitamin D3 concentration (an indicator of vitamin D levels) was significantly associated with an increased risk of glaucoma in women compared to those with higher 25-hydroxyvitamin D3.
    The results of this study indicated that vitamin D status independently affects glaucoma pathophysiology in women, although the study authors were unable to explain the exact mechanism responsible. They did conclude however, that with the presence of a primary factor, a low vitamin D level might leave the optic nerve more vulnerable to glaucoma.
  15. Vitamin D and VDR in Gynecological Cancers—A Systematic Review                     (Deuster et al., 2017)                                                                                                                         A large number of studies have displayed the crucial role vitamin D and its receptor have in gynaecological cancers. Preclinical, as well as epidemiological evidence, supports vitamin D’s risk-reducing influence in gynaecologic carcinomas . It is a widely shared opinion that vitamin D supplementation decreases the risk of developing cancer.
  16. The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention (Guo et al,2018)                                                                                                                               The role of Vitamin D in human cancers, including ovarian cancer, has been widely investigated, where it was proposed to play a protective and antitumorigenic role by regulating cellular proliferation and metabolism. In this review, we have shown that vitamin D status may be an independent predictor of prognosis in ovarian cancer patients.Vitamin D combination therapy improves antitumor effects allowing for potential clinical application. Supplement of vitamin D and calcium combination may be an efficient method for cancer prevention.
  17. Vitamin D Deficiency and Antenatal and Postpartum Depression: A Systematic Review (Aghajafari et al, 2018)                                                                                                                            Based on the systemic evaluation of the previous literature in the field, there may be an association between lower vitamin D status and increased risk of depressive symptoms during and after pregnancy. While the quality of the available evidence was not always optimal due to lower methodologic quality of the studies, this review provides an analysis of the methodological issue that future supplementation studies need to consider in their research design.
  18. Vitamin D3 Versus Gliadin: A Battle to the Last Tight Junction                           (Scricciolo et al, 2018)                                                                                                                                           The positive impact of vitamin D on tight junctions could be used in celiac disease therapy to prevent the passage of peptides into the lamina propria, that enhances the inflammatory process.The findings related to intestinal barrier damage and the benefit from vitamin D use, suggest its application to other gluten-related disorders (such as non-celiac gluten sensitivity), where the presence of altered intestinal permeability is proven.
  19. Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts (McCullough et al, 2019)                                                                                   Higher vitamin D levels are associated with a substantially lower bowel cancer (BC) risk in women. Optimal BC risk reduction vitamin D levels are greater than existing IOM recommendations